Xenical vs. Meridia Which is best for you? Xenical is one of just two weight-loss drugs now on the market that are FDA-approved for long-term use (that is, longer than one year). The other is Meridia, which has been available in the United States since early 1998. By altering chemicals in the brain that control feelings of hunger and fullness, Meridia also promotes modest weight loss in dieters. Like Xenical, it's only for those who are obese and who have failed at Weight Watchers or other weight-loss plans. Which is best for you? Meridia is for people who eat the right foods but just eat too much. Xenical is better for those who can’t stick to a low-fat diet. Because Xenical cuts fat absorption, someone who eats a lot of fat while taking the drug will end up having frequent, oily bowel movements and excess gas. That's a wake-up call to eat less fat. These side effects may motivate people to diet more effectively and deter them from abusing Xenical. I don't think people are going to want this drug unless they're serious about losing weight. The good news is that the side effects improve within two to three weeks as the colon adapts to the drug. Because Xenical acts only in the gastrointestinal tract, it doesn't appear to cause side effects elsewhere in the body, which means it's safer than most diet drugs. But it apparently does lower absorption of some fat-soluble vitamins, which is why users are advised to take a supplement that contains vitamins A, D, E and K, plus beta carotene. The truth is, anyone on a diet should be taking a supplement — a generic multivitamin is fine.

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