Meridia SIBUTRAMINE (Systemic) Sibutramine (si-BYOO-tra-meen) is used in combination with a reduced-calorie diet to help you lose weight and to keep the lost weight from returning. Sibutramine is thought to work by increasing the activity of certain chemicals, called norepinephrine and serotonin, in the brain. This medicine is approved for use only in people who are very overweight. Meridia works as Phen-Fen did but in one pill. Meridia's actions which are similar to phentermine include the potentiation of dopamine and norepinephrine in the body, which are hormones that cause the appetite to be reduced. Meridia also increases serotonin, another hormone, as fenfluramine did, resulting in a feeling of fullness. Clinical studies so far have not shown Meridia to increase the risk of heart valve abnormalities that fenfluramine supposedly caused.   Meridia represents an exciting addition to the rapidly expanding field of medications available to assist individuals in losing weight. This medicine is available only with your doctor's prescription.

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